Cytotoxic Effects of Singlet Oxygen

Cytotoxic effects of singlet oxygen.

The toxic effects of gas-phase singlet oxygen, 1O2, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with 1O2 showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary activity occurred at 1O2 concentrations as low as 154 ppb after a 2-hr exposure. Cytological alte...

Singlet Oxygen

Singlet oxygen (O2) is a higher energy state molecular oxygen species. It is one of the most active intermediates involved in chemical and biochemical reactions. To fully appreciate the reactivity of O2, it is necessary to understand its physical and chemical nature. This paper reviews the generation, quenching and detection of O2. Its properties, possible chemical reactions are presented as we...

Photosensitized effects of furocoumarins: the possible role of singlet oxygen.

The capacity of various furocoumarins to generate singlet oxygen in aqueous solution has been determined. The antiproliferative and the skin-photosensitizing activities of the same furocoumarins did not show any correlation with the capacity to generate the singlet oxygen, while these photobiological properties could be correlated with the capacity of furocoumarins to induce photolesions to the...

Singlet Oxygen Trapping Porphyrins

Effects of singlet oxygen on human lens crystallins in vitro.

We have recently demonstrated that singlet oxygen-mediated photooxidation can cause an increase in blue fluorescence and covalent cross-linking in bovine lens crystallins in vitro. Because these changes closely parallel modifications known to occur in human crystallins during aging and cataractogenesis, it was suggested that singlet oxygen may play an important role in these processes in vivo. ...